This collection includes theses and dissertations from the Department of Pharmacology and Toxicology, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2022

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Etracellular vesicles from lactobacillus rhamnosus GG protect against alcohol-induced liver injury through suppression of intestinal MIR 194 and subsequent activation of FXR in mice., Mengwei Jiang

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Translating particulate hexavalent chromium-induced chromosome instability from human lung cells to experimental animals, human lung tumors and whale cells., Haiyan Lu

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A modeling platform to predict cancer survival and therapy outcomes using tumor tissue derived metabolomics data., Hunter Allan Miller

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Tobacco-derived aldehydes, platelets, and thrombogenicity: role of transient receptor potential ankyrin-1., Andre D. Richardson

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Cannabinoids and retinal fibrotic disorders., Lucy June Sloan

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Molecular mechanisms of hexavalent chromium-induced centrosome amplification., Jennifer Haruka Toyoda

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The roles of PON2 in mitochondrial physiology, lung tumor cell proliferation, and lung tumorigenesis., Aaron Whitt

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Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts., Aggie R. Williams

Theses/Dissertations from 2021

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Histone deacetylases in alcohol associated Liver disease., Srineil Bodduluri

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Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans., Matthew William Dent

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Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism., Marc Matthew Dwenger

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PDE4 inhibition: a novel therapeutic strategy in liver fibrosis., Mohamed Elnagdy

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Investigating the effects of Perfluorooctanoic Sulfonate (PFOS) and ethanol on fatty liver disease using a modified NIAAA model., Tyler Charles Gripshover

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The role of sphingolipids in AKI and the progression to CKD: potential therapuetic targets., Nicholas A. Hoffman

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Assessing the role of chronic arsenite exposure in disrupting the EGFR signaling axis., Christine Kim

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The role of Src in NSCLC cell and lung fibroblast migration on 3D cell-derived matrix., Austin M Krueger

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Assessing the role of arsenic exposure and MIRNA-186 in skin tumorigenesis and chromosomal instability., Angeliki Lykoudi

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Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury., Andrew Joseph Orwick

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Role of KVβ2 subunits in regulation of resistance arterial tone., Sean M Raph

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Preclinical development of epicertin, a novel biotherapeutic for the treatment of ulcerative colitis., Micaela Ann Reeves

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Characterizing the role of macrophages in cisplatin-induced kidney injury and progression to chronic kidney disease., Sophia M. Sears

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Heterocyclic amines and arylamine N-acetyltransferase 2 polymorphism in pathogenesis of insulin resistance., Kennedy M. Walls

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Oligodendrocyte responses after spinal cord injury., George Zach Wei

Theses/Dissertations from 2020

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Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle

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N-Acetyltranserase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells., Mariam Refaat Zaky Habil

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A novel role for RASSF1A in the regulation of RAS activation., Desmond Ramón Harrell Stewart

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Evaluating the effects of PCBs in non-alcoholic fatty liver disease & diabetes and the role of AhR in regulating the hepatic proteome and lipid metabolism., Jian Jin

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The cardiovascular effects of tobacco product-derived aldehydes: contribution of transient receptor potential ankyrin-1., Lexiao Jin

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Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease., Fengyuan Li

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Sulforaphane protects against ethanol-induced apoptosis and teratogenesis through epigenetic modulation of anti-apoptotic genes., Yihong Li

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Tobacco product-derived aldehydes: effects on circulating angiogenic cells & implications for cardiovascular disease., Jordan B. Lynch

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Exosomes from embryonic stem cells as a prophylactic vaccine against lung cancer., Shuhan Meng

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Tobacco-derived aldehydes: platelet activation, thrombosis, and the role of TRPA1., Andre Dwayne Richardson

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Mechanisms of chromate-induced suppression of RAD51: a one environmental health approach., Rachel M. Speer

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Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease., Jeffrey Barr Warner

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The effects of whole life, low dose cadmium exposure on high fat diet-induced nonalcoholic fatty liver disease and the role of zinc., Jamie Lynn Young

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The role of Slc7a11 in controlling extracellular and intracellular redox environments of lung fibroblasts - potential targets for intervention in aging and idiopathic pulmonary fibrosis., Yuxuan Zheng

Theses/Dissertations from 2019

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Characterization of a more clinically relevant human leukemia xenograft model to examine perturbation of MET/SAM metabolism as a novel therapeutic paradigm for MLL-R leukemia in vivo., Aditya Barve

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Development of a lectin-Fc fusion protein with antiviral and anti-cancer activity., Matthew William Dent

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Novel mechanisms and biomarkers in alcohol-induced organ injury., Christine E. Dolin

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Therapeutic potential of withaferin A against non-small cell lung cancer., Al Hassan Kyakulaga

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Development of BAR-peptide nanoparticles and electrospun fibers for the prevention and treatment of oral biofilms., Mohamed Yehia Mahmoud

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A recombinant cholera toxin b subunit variant (CTB-KDEL) exhibits unique colon mucosal healing effects that have therapeutic implications for inflammatory bowel disease., Joshua Mark Royal

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Characterizing the role of extracellular matrix in non-small cell lung carcinoma metastasis using a 3D microenvironment mimetic in-vitro culture system., Douglas John Owulaku Saforo

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Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury., Sophia M. Sears

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Electrospun fibers and nanoparticles for the prevention of sexually transmitted infections., Kevin Michael Tyo

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Paraoxonase 2 is critical for non-small cell lung carcinoma proliferation., Aaron Whitt

Theses/Dissertations from 2018

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Deciphering the role of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer cell metabolism using a systems biology approach., Samantha Marie Carlisle

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The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet., Liya Chen

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Maturation of human induced pluripotent stem cell derived engineered cardiac tissues using chief transfection and chronic optical pacing., Marc M. Dwenger

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A cancer-targeted gold nanoparticle-based MRI contrast agent., Nagwa El-Baz

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EGFR signaling from the early endosome., Julie A. Gosney

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Assessing the role of arsenite in disrupting the EGFR signaling axis., Christine Kim

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Vinyl chloride enhances diet-induced liver injury via metabolic dyshomeostasis : critical role of mitochondria., Anna L. Lang

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A study of GPR3, GPR6, of GPR12 as novel molecular targets for cannabidiol., Alyssa S. Laun

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A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes., Qian Lin

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Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age., Ryan Carroll McAllister

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Evaluation of drug-loaded gold nanoparticle cytotoxicity as a function of tumor tissue heterogeneity., Hunter Allan Miller

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Influence of bilberry-derived anthocyanidins on key regulators of colorectal cancer development., Ashley M. Mudd

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Wnt/β-Catenin mediated cancer stem cell activation in hepatocellular carcinoma., Harshulkumar M. Pandit

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Therapeutic potential of a plant-made cholera toxin b subunit variant for the treatment of ulcerative colitis., Joshua Mark Royal

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Epidermal growth factor-like ligands regulate dimer selection., Jamie S. Rush

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A clinically relevant mouse model of cisplatin-induced kidney injury., Cierra Nichole Sharp

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The effects of polychlorinated biphenyls exposure on non-alcoholic fatty liver disease : role of aryl hydrocarbon receptor., Hongxue Shi

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Particulate hexavalent chromium does not induce centrosome amplification in sperm whale and bowhead whale cells., Jennifer Haruka Toyoda

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A model to study the effects of whole life chronic exposure to arsenic or cadmium on the development of adult metabolic syndrome : initial characterization of hepatic changes., Jamie L. Young

Theses/Dissertations from 2017

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MiRNA expression changes in arsenic-induced skin cancer in vitro and in vivo., Laila Al-Eryani

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The effects of moderate alcohol consumption and inflammation on the hepatic matrisome and the renal cortex proteome., Christine E. Dolin

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Age-related host factors regulate lung cancer progression., John Caleb Greenwell

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Targeting the glucose metabolism of myeloid-derived suppressor cells (MDSCs) to stimulate cancer immunity., Jaspreet Grewal

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Targeting the major regulator of mitosis., J. Mason Hoffman

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Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy., Elizabeth Marie Hollis

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Identifying the signaling mechanisms of EGFR-mediated apoptosis., Nicole Marion Jackson

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Advances in tumor-targeted therapy using nanomedicine., Divya Karukonda

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UBQLN1 : a multi-domain protein with multiple functions., Zimple Kurlawala

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Withaferin a synergistically enhances the effects of paclitaxel against lung cancer., Al Hassan Kyakulaga

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Prevention and treatment of familial adenomatous polyposis and colorectal cancer by bilberry-derived anthocyanidins., Ashley M. Mudd

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The interaction of homoserine lactones and paraoxonase 2 modulates cell death signaling and cell proliferation., Aaron Mackallan Neely

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Novel insight into the liver-lung axis in alcohol-enhanced acute lung injury., Lauren G. Poole

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The role of HIF-1α in intestinal epithelial barrier function in alcoholic liver disease., Tuo Shao

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Combating malignant melanoma with the multifaceted soy-dervied peptide lunasin., Christopher Paul Shidal

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The comparative cytotoxicity and genotoxicity of hexavalent chromium in humans and sea turtles., Rachel M. Speer

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Role of human arylamine n-acetyltransferase 1 in tumorigenesis and cancer biology., Marcus William Stepp

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Characterization of a mutant oncolytic adenovirus and the role of jnk in enhancing virotherapy., Stephen L. Wechman

Theses/Dissertations from 2016

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Role of phosphodiesterase-4 in alcohol-induced organ injury., Diana Veronica Avila

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Establishing a clinically relevant mouse model of human AML to test novel transmethylation inhibitors., Aditya Barve

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Acrolein is a critical mediator of alcohol-induced liver and intestinal injury in alcoholic liver disease., Wei-Yang (Jeremy) Chen

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Air pollution, pulmonary oxidative stress, and the endothelin system in the development of cardiovascular injury., Jordan B. Finch

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Isolation of EGFR-containing early endosomes., Julie A. Gosney

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The role of the nucleolus in neurodegeneration., Justin Lauren Hallgren

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Pro-inflammatory cytokines promote viral replication and cell cycle mediators in arenavirus-induced hepatitis., Gretchen E. Holz

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MicroRNA-186 and metastatic prostate cancer., Dominique Zilpha Jones

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Vinyl chloride-diet interactions in liver disease : potential roles of autophagy and energy management., Anna L. Lang

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Modulation of cell death signaling and cell proliferation by the interaction of homoserine lactones and Paraoxonase 2., Aaron Mackallan Neely

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Developing a more clinically-relevant mouse model of cisplatin-induced nephrotoxicity., Cierra N. Sharp

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Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections., Kevin Tyo

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The role of nicotine, a7 nicotinic acetylcholine receptors and extracellular matrix remodeling in pulmonary fibrosis., Glenn Ward Vicary

Theses/Dissertations from 2015

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Promoting differentiation and survival of human c-kit+ cardiac progenitor cells ex vivo., Tareq Al-Maqtari

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A plant-made cholera toxin B subunit enhances mucosal wound healing and protects against ulcerative colitis and colon cancer., Keegan J Baldauf

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Metabolomics of transformed MDA-MB-231 cell lines expressing different levels of human arylamine N-acetyltransferase 1 (NAT1)., Samantha Marie Carlisle