This collection includes theses and dissertations from the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to 2014 can be accessed in the University of Louisville Libraries. If you would like to add your thesis or dissertation to this collection, please fill out the Electronic Theses & Dissertations form.

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Theses/Dissertations from 2022

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The impact of volume of tissue activation on cortical-striatal networks and verbal fluency declines in post-deep brain stimulation Parkinson's disease patients., Alexander Luke Alley

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The effect of telepractice on vocal interaction between provider, deaf and hard-of-hearing pediatric patients, and caregivers., Abigail Betts

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Adipose-derived stromal vascular fraction therapy improves age-related adrenergic mediated microvascular dysfunction and increases revascularization potential following injury., Gabrielle Brown

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Critical thinking or critical creativity: applying De Bono's six thinking hats to speech-language pathology education and practice., Samantha Hahn

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Etracellular vesicles from lactobacillus rhamnosus GG protect against alcohol-induced liver injury through suppression of intestinal MIR 194 and subsequent activation of FXR in mice., Mengwei Jiang

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Genomic tools and models for investigating the role of germline diversity in mouse antibody repertoire development., Justin T. Kos

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A modeling platform to predict cancer survival and therapy outcomes using tumor tissue derived metabolomics data., Hunter Allan Miller

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Aggregatibacter actinomycetemcomitans exploits and modulates the immune response by human neutrophils for survival in the anaerobic environment., Hazel Ozuna

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The role of obesity in macrophage-mediated mechanisms promoting early-onset colon cancer., Katharina Marietta Scheurlen

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Cannabinoids and retinal fibrotic disorders., Lucy June Sloan

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Lysosomal evasion of legionella pneumophilia the effector., Bethany Vaughn

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The roles of PON2 in mitochondrial physiology, lung tumor cell proliferation, and lung tumorigenesis., Aaron Whitt

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Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts., Aggie R. Williams

Theses/Dissertations from 2021

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Impact of PANK1 deletion on mitochondrial acetylation and cardiac function during pressure overload., Timothy N. Audam

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Anxiety and self-efficacy related to learning neuroanatomy in an integrated medical curriculum., Jessica S. Bergden

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Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis., Rumeysa Biyik-Sit

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Histone deacetylases in alcohol associated Liver disease., Srineil Bodduluri

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Effects of chemosensory experience and context on consummatory behaviors., Saphira M. Chiu

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Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans., Matthew William Dent

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Genetic and functional analysis of rat mammary cancer susceptibility., Emily L Duderstadt

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Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism., Marc Matthew Dwenger

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PDE4 inhibition: a novel therapeutic strategy in liver fibrosis., Mohamed Elnagdy

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Harnessing the power of trained immunity in the setting of pancreatic cancer: a novel mechanism of immune trafficking and tumor control., Anne Elena Geller

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Investigating the effects of Perfluorooctanoic Sulfonate (PFOS) and ethanol on fatty liver disease using a modified NIAAA model., Tyler Charles Gripshover

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Investigations of potential mechanisms underlying spinal cord injury-induced polyuria., Jason H. Gumbel

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Sex-based differences in microbiota composition and metabolomic profiles associated with altered macrophage function and protection from lupus in BWF1 mice., James William Harder

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The role of sphingolipids in AKI and the progression to CKD: potential therapuetic targets., Nicholas A. Hoffman

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Assessing the role of chronic arsenite exposure in disrupting the EGFR signaling axis., Christine Kim

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The role of Src in NSCLC cell and lung fibroblast migration on 3D cell-derived matrix., Austin M Krueger

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The importance of noncapped viral genomic RNA to alphaviral infection and pathogenesis., Autumn LaPointe

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Assessing the role of arsenic exposure and MIRNA-186 in skin tumorigenesis and chromosomal instability., Angeliki Lykoudi

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Q-Griffithsin interactions and utility for the prevention and treatment of Mucosal infections., Henry Nabeta

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Metabolic-epigenetic regulation of macrophage polarization., Jordan T. Noe

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An analysis of taste neuron morphological variability: influences of neuron type and plasticity., Lisa Christina Ohman

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Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury., Andrew Joseph Orwick

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Role of KVβ2 subunits in regulation of resistance arterial tone., Sean M Raph

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Preclinical development of epicertin, a novel biotherapeutic for the treatment of ulcerative colitis., Micaela Ann Reeves

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Characterizing the role of macrophages in cisplatin-induced kidney injury and progression to chronic kidney disease., Sophia M. Sears

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Determination of the biological functions of undefined domains of VEEV nsP2., Andrew Michael Skidmore

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Role of meibum and tear phospholipids in the evaporative water loss associated with dry eye., Samiyyah M. Sledge

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Heterocyclic amines and arylamine N-acetyltransferase 2 polymorphism in pathogenesis of insulin resistance., Kennedy M. Walls

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Oligodendrocyte responses after spinal cord injury., George Zach Wei

Theses/Dissertations from 2020

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Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury., Adrienne M. Bushau-Sprinkle

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Formation, organization, and synaptic properties of circuits between thalamic reticular nucleus and dorsal lateral geniculate nucleus., Peter W. Campbell

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The retinoblastoma protein mediates metabolic reprogramming in lung cancer., Lindsey R. Conroy

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Autism Spectrum Disorder: investigating predictive adaptive behavior skill deficits in young children., Emma L. Feige

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N-Acetyltranserase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells., Mariam Refaat Zaky Habil

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Plasmodium impairs antibacterial innate immunity to systemic infections in part through hemozoin-bound bioactive molecules., Christopher Lynn Harding

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A novel role for RASSF1A in the regulation of RAS activation., Desmond Ramón Harrell Stewart

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Evaluating the effects of PCBs in non-alcoholic fatty liver disease & diabetes and the role of AhR in regulating the hepatic proteome and lipid metabolism., Jian Jin

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The cardiovascular effects of tobacco product-derived aldehydes: contribution of transient receptor potential ankyrin-1., Lexiao Jin

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Development of rationally designed live attenuated vaccines for Lassa fever and Venezuelan equine encephalitis., Dylan MacGregor Johnson

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Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease., Fengyuan Li

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Sulforaphane protects against ethanol-induced apoptosis and teratogenesis through epigenetic modulation of anti-apoptotic genes., Yihong Li

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Tobacco product-derived aldehydes: effects on circulating angiogenic cells & implications for cardiovascular disease., Jordan B. Lynch

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Hearing loss: investigating the comfort, confidence, knowledge, and preparedness of Kentucky school-based speech-language pathologists., Amanda Matsumoto

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Exosomes from embryonic stem cells as a prophylactic vaccine against lung cancer., Shuhan Meng

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The emerging oral pathogen, filifactor alocis, disrupts neutrophil functions to enhance survival and dysregulate inflammation., Irina Miralda Molina

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Structural characterization and selective drug targeting of higher-order DNA G-quadruplex systems., Robert Chandos Monsen

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Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through NF-Kβ dependent glycolytic metabolic reprogramming., Samantha M. Morrissey

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Modulation of inflammatory pathway by inflammatory inhibitor JSH-23 mitigates diabetic retinopathy., Rubens Petit Homme

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Modulation of host innate immune cells by Yersinia pestis to create a permissive environment for replication., Amanda Rose Pulsifer

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Tobacco-derived aldehydes: platelet activation, thrombosis, and the role of TRPA1., Andre Dwayne Richardson

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Identification and structural characterization functional motifs in the Porphyromonas gingivalis MFA1 short fimbria., Mohammad K. Roky

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Transient display of chimeric proteins on biological surfaces as an effective strategy for modulations of innate and adaptive immune responses., Pradeep Shrestha

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Mechanisms of chromate-induced suppression of RAD51: a one environmental health approach., Rachel M. Speer

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Tissue-resident myeloid-derived suppressor cells modulate immune homeostasis in healthy adipose., Katlin Brooke Stivers

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Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease., Jeffrey Barr Warner

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The effects of whole life, low dose cadmium exposure on high fat diet-induced nonalcoholic fatty liver disease and the role of zinc., Jamie Lynn Young

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The role of Slc7a11 in controlling extracellular and intracellular redox environments of lung fibroblasts - potential targets for intervention in aging and idiopathic pulmonary fibrosis., Yuxuan Zheng

Theses/Dissertations from 2019

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A distinct pattern of sterile inflammation induced by zinc oxide nanowires., Ruqaih Salem Alghsham

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Characterization of a more clinically relevant human leukemia xenograft model to examine perturbation of MET/SAM metabolism as a novel therapeutic paradigm for MLL-R leukemia in vivo., Aditya Barve

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Development of a lectin-Fc fusion protein with antiviral and anti-cancer activity., Matthew William Dent

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Understanding object motion encoding in the mammalian retina., Victor Julian DePiero

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Novel mechanisms and biomarkers in alcohol-induced organ injury., Christine E. Dolin

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Inspiratory muscle recruitment during swallow and a comparison across airway behaviors., Allison V. English

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Alterations in rhythmic licking behaviors following fibrosis in the rat mylohyoid muscle., Brittany Fletcher

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Coordination of airway protective behaviors and swallow: effects of afferent feedback and sex., Alyssa D. Huff

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The effects of nicotine and cigarette smoking on cardiac electrophysiology., Affan B. Irfan

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Therapeutic potential of withaferin A against non-small cell lung cancer., Al Hassan Kyakulaga

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Development of BAR-peptide nanoparticles and electrospun fibers for the prevention and treatment of oral biofilms., Mohamed Yehia Mahmoud

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Preference for odor-taste mixtures is dependent on previous experience., Kelsey Allison McQueen

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Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression., Stephanie Metcalf

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The identification of long non-coding RNA ZFAS1 through an exploratory RNA-sequencing analysis and its association with epithelial-to-mesenchymal transition in colon cancer adenocarcinoma., Stephen J. O'Brien

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Glycine receptor expression across identified retinal ganglion cell types., Ian Scot Pyle

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A recombinant cholera toxin b subunit variant (CTB-KDEL) exhibits unique colon mucosal healing effects that have therapeutic implications for inflammatory bowel disease., Joshua Mark Royal

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Characterizing the role of extracellular matrix in non-small cell lung carcinoma metastasis using a 3D microenvironment mimetic in-vitro culture system., Douglas John Owulaku Saforo

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Investigating predictive relationships between speech-language pathology graduate students' sense of classroom community, perceived learning, and perceived anxiety., Emily B. Schantz

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Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury., Sophia M. Sears

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The self-efficacy of biological mothers and foster mothers caring for infants prenatally exposed to drugs or treated for NAS : examination of potentially influencing factors., Megan Kathleen Sherehiy

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The effect of spinal cord injury on sexual function., Casey J. Steadman

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Electrospun fibers and nanoparticles for the prevention of sexually transmitted infections., Kevin Michael Tyo

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The manipulation of host transcription by the ANKH effector of legionella., Juanita E. Von Dwingelo

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Paraoxonase 2 is critical for non-small cell lung carcinoma proliferation., Aaron Whitt

Theses/Dissertations from 2018

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Nutritional virulence of Legionella pneumophila., Ashley M. Best

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Combination oral immunotherapy with IL-10 and IL-12 effectively treats colon tumors via synergistic effects on IL-17 producing T cells and colon epithelial barrier integrity., Neal Bhutiani

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Unfolded protein response pathways in skeletal muscle homeostasis., Kyle R. Bohnert

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Deciphering the role of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer cell metabolism using a systems biology approach., Samantha Marie Carlisle

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The migration and developmental remodeling of intrinsic interneurons in visual thalamus and the role of retinal signaling., Naomi E. Charalambakis

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The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet., Liya Chen